I've heard that CBD can interact with many drugs. Are there interactions with Prednisone and CBD oil?
Joel Taylor (Thursday, August 12, 2021):
Both CBD oil and Prednisone are inhibitors of the cytochrome P450 enzyme CYP3A, which means that taking both of them together would result in them having to compete for metabolism. What this means is that the interactions with CBD oil and Prednisone could be dangerous, potentially leading to increased side effects from both. If you are on Prednisone or any other medication, you should talk to your doctor before deciding to try CBD oil as well. Additionally, give it a few hours in between doses to minimize adverse reactions as much as possible.
Osasere Okunloye (Thursday, August 12, 2021):
Studies show that CBD can interact with Prednisone by inhibiting the same enzyme (Cytochrome P450 enzyme CYP3A) as prednisone, and using both of them together may decrease glucocorticoid clearance and increase side effects of Prednisone. Before taking CBD with prednisone or any other medication, you should seek professional advice from a doctor. Reply Follow Share Avik Das Wednesday, January 12, 2022 No, it is not safe to use CBD oil while taking Prednisone simultaneously. CBD can inhibit CYP3A in the body, but Prednisone is also known to inhibit CYP3A in the body. Therefore, using them together might give good results in glucose clearance, but facing systemic side effects is inevitable. It is always best to consult a doctor before using CBD oil with Prednisone.