Does CBD Interact With Nortriptyline and Sertraline? - Cannabotech CBD Questions & Answers

Does CBD Interact With Nortriptyline and Sertraline?

CBD might interact with various medications, including Nortriptyline and Sertraline.

By Alex Saez
Joel Taylor - writer and editor for Cannabotech
Edited by Joel Taylor

Updated April 7, 2023.

CBD may interact with Nortriptyline and Sertraline, depending on how your body metabolizes those medications. The liver contains several types of enzymes to break down different substances - including your medication. While some medicines are fine to mix with ingested CBD, others could cause serious health issues. So, can you take CBD with Sertraline and Nortriptyline?

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CBD and the Liver

CBD is broken down using the CYP450 liver enzyme family. However, many medications also rely on that enzyme. Adding those together at once could destabilize your prescription medication, causing you to process it too slowly. Consequently, you may notice increased side effects or decreased efficacy.

Does CBD Interact With Sertraline?

Sertraline is the generic drug name for Zoloft, a popular anti-depressant and anxiolytic drug. Taking CBD and sertraline together may cause some complications.

According to the drug's warnings, CBD can trigger or worsen effects like dizziness, drowsiness, poor attention, clumsiness, and impaired judgment. It can also lead to respiratory depression, which affects breathing.

Does CBD Interact With Nortriptyline?

Nortriptyline also negatively interacts with CBD. Like Sertraline, Nortriptyline is a mood stabilizer used to treat conditions like depression and anxiety.

The possible complications with CBD are completely identical to Sertraline, including respiratory effects.


CBD offers a lot of potential benefits, but for some people, cannabidiol isn't safe. We didn't always know about these risks. Although we have a growing list, there's no telling how many other medications won't work well with CBD.

As a rule of thumb, any medication that won't allow you to simultaneously consume grapefruit is virtually guaranteed to conflict with CBD.

Ultimately, you can't take chances with your health. It's great to consider CBD as a complementary part of your wellness routine. However, don't start until you speak to a doctor.