What are the effects of interactions between CBD oil and Methotrexate? - Cannabotech

What are the effects of interactions between CBD oil and Methotrexate?

Asked 3 years ago

I have Rheumatoid Arthritis and Ehlers Danlos syndrome and I want to take CBD oil for the pain but I am unsure if I can. Does CBD oil interact with Methotrexate?

Methotrexate Drug interaction Rheumatoid arthritis Pain relief

Osasere Okunloye

Thursday, June 17, 2021

CBD is metabolised in the liver by the cytochrome p450 enzymes(CYP3A4 enzyme). This enzyme is also responsible for the metabolism of methotrexate. There are potential interactions between CBD and methotrexate that can lead to a slower metabolism causing an accumulation of these drugs in the system. Proceed with caution, see a doctor before taking CBD with any other medication.